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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD105 (Endoglin, gp160, TGF beta1,3 Receptor) (APC)

Anti -CD105 (Endoglin, gp160, TGF beta1,3 Receptor) (APC)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
CD105, also known as Endoglin, is a disulfide-linked homodimeric type I transmembrane glycoprotein (1, 2). Two isoforms of CD105, a short form and a long form, differ by 33 amino acids (aa) in their cytoplasmic tails (3). The long form (180kD in size) is considered the predominant form of the protein although both isoforms have been detected by RT-PCR in endothelial cells, monocytic cell lines, and placenta (3, 4). CD105 serves as the regulatory component of the TGF-Beta receptor complex by associating with TGF-Beta receptor I and II (5, 6). These receptor complexes efficiently bind TGF-Beta1 and TGF-Beta3 with high affinity (5, 7). CD105 also binds other members of the TGF-Beta superfamily including activin-A, BMP-7 and BMP-2 (5). Functionally, CD105 plays an important role in angiogenesis (7, 8), hematopoiesis (9, 10) and cardiac development (9). CD105 was also shown to be a functional marker that defines long-term repopulating hematopoietic stem cells from the bone marrow “side-population” cells (11). Multipotent stem cells have been isolated from bone marrow and muscle tissue based on their expression of CD105 (12, 13). Clinically, mutations in the gene for CD105 result in the autosomal dominant disorder Hereditary Hemorrhagic Telangiectasia Type 1 (14). In addition, soluble levels of shed CD105 have been associated with poor prognosis in breast, colorectal and other types of cancer (15, 16). Further investigations may elucidate the role of CD105 and its ligands in a variety of biologic processes.
Catalog #C2446-50K1
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: Use 10ul to label 10e5 cells.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4°C. Freezing allophycocyanin conjugates will result in a substantial loss of activity. Allophycocyaninconjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8H109
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in PBS, 0.1% sodium azide. Labeled with APC.
PurityPurified by Protein G affinity chromatography.
ImmunogenNS0-derived rhEndoglin extracellular domain
SpecificityRecognizes human CD105.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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