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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified IH

CD105 or Endoglin or GP160 is a 75kD type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists as an O- and N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. CD105 binds to TGF1 and 3 with high affinity but not TGF- alpha-2.
Catalog #	C2446-50L
Applications	Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution	Immunohistochemistry: 1:50 for 30min at RT
	Staining of formalin-fixed tissues requires boiling tissues sections in 10mM citrate buffer, pH 6.0, for 10min followed by cooling at RT for 20min
	Optimal dilutions to be determined by the researcher.
Positive Control	Tonsil
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Host	Rabbit
Source	Human
Concentration	~0.1mg/ml
Form	Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Recombinant correspondingg to aa26-176 from human CD105.
Specificity	Recognizes human CD105.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.