CD105, Recombinant, Human (Endoglin, gp160, TGF beta1,3 Receptor, ENG, END, ORW, HHT1,
ORW1, FLJ41744)
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| CD105 (26-176 a.a.) or Endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. It exists as an O- and N-glycosylated homodimer of 180kD. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. Endoglin has been found to be part of the TGF-beta1 receptor complex. It thus may be involved in the binding of TGF-beta1, TGF beta3, activin-A, BMP-2, and BMP-7. CD105 binds to TGF Beta1 and Beta3 with high affinity but not TGF-Beta2Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. Experimental mice without the endoglin gene die due to cardiovascular abnormalities. | | | Catalog # | C2446-50R | | CD105 Human Recombinant extracellular domain produced in E. coli is a single, glycosylated, polypeptide containing 151 amino acids (26-176) and having a molecular mass of 43kD. | | Applications | Suitable for use in ELISA, Inhibition Assays, Western Blotting. | | Storage and Stability | Endoglin although stable at 15°C for 1 week, should be stored desiccated below -18°C. | | For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). | | Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles. | | Molecular Weight | 43kD | | Source | E. coli | | Purity | 90%. Analysis by RP-HPLC. Chromatographically purified. On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 43kD. | | Concentration | ~0.1mg/ml | | Form | Supplied as a sterile-filtered liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA and 20% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for CD105, Recombinant, Human (Endoglin, gp160, TGF beta1,3 Receptor, ENG, END, ORW, HHT1, ORW1, FLJ41744) |
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