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You are here:Home » Antibodies » Abs to Disease Markers » Anti -CD105 (CD105 Antigen, Endoglin, END, ENG, FLJ41744, HHT1, Osler-Rendu-Weber Syndrome 1, ORW1, ORW)

Anti -CD105 (CD105 Antigen, Endoglin, END, ENG, FLJ41744, HHT1, Osler-Rendu-Weber Syndrome
1, ORW1, ORW)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Mutations in the gene encoding endoglin have been linked to the human disease hereditary hemorrhagic telangiectasia type 1 (HHT1) a vascular disorder characterized by localized vascular dysplasia and a tendency towards arteriovenous malformations. Mice expressing a single CD105 allele develop external signs of disease similar to human HHT1, supporting the haploinsufficiency model for HHT1. Mice lacking endoglin die from defective angiogenesis characterized by failure of vascular smooth muscle investment of embryonic blood vessels, suggesting a defect in vascular smooth muscle cell development. Microvessel density (MVD) has been reported to be an independent prognostic indicator of outcome in a variety of human malignancies, with increased MVD correlating with shorter overall and relapse-free survival rates. The MVD counts using anti-CD105 antibody significantly correlated with overall and disease-free survival.
Catalog #C2446-51E
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgGA
Clone NoMEM-226
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 15mM sodium azide, pH7.4.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman CD105.
SpecificityRecognizes human broadly expressed CD98 antigen (also known as 4F2), 80+40kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesRP11-228B15.2


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