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Anti -CD105 (CD105 Antigen, Endoglin, END, ENG, FLJ41744, HHT1, Osler-Rendu-Weber Syndrome 1, ORW1, ORW) (FITC)
Anti -CD105 (CD105 Antigen, Endoglin, END, ENG, FLJ41744, HHT1, Osler-Rendu-Weber Syndrome
1, ORW1, ORW) (FITC)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
FC |
|
| Mutations in the gene encoding endoglin have been linked to the human disease hereditary hemorrhagic telangiectasia type 1 (HHT1) a vascular disorder characterized by localized vascular dysplasia and a tendency towards arteriovenous malformations. Mice expressing a single CD105 allele develop external signs of disease similar to human HHT1, supporting the haploinsufficiency model for HHT1. Mice lacking endoglin die from defective angiogenesis characterized by failure of vascular smooth muscle investment of embryonic blood vessels, suggesting a defect in vascular smooth muscle cell development. Microvessel density (MVD) has been reported to be an independent prognostic indicator of outcome in a variety of human malignancies, with increased MVD correlating with shorter overall and relapse-free survival rates. The MVD counts using anti-CD105 antibody significantly correlated with overall and disease-free survival. | | | Catalog # | C2446-51F | | Applications | Suitable for use in Flow Cytometry. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 20ul reagent/100ul sample. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | MEM-226 | | Host | Mouse | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid in PBS, BSA, 15mM sodium azide, pH7.4. Labeled with FITC. | | Purity | Purified | | Immunogen | Human CD105. | | Specificity | Recognizes human CD105. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | RP11-228B15.2 |
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