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Anti -CD105 (Endoglin, gp160, TGF beta1,3 Receptor)
Anti -CD105 (Endoglin, gp160, TGF beta1,3 Receptor)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IP IH FC |
|
| Endoglin is a 190kD homodimeric transmembrane glycoprotein composed of disulfide-linked subunits. The external domain binds TGF-beta1 and -beta3 isoforms with high affinity. Two different isoforms (L and S) of CD105 with capacity to bind TGF-beta have been characterized which differ in the amino acid composition of their cytoplasmic tails. Mutations in the gene encoding endoglin have been linked to the human disease hereditary hemorrhagic telangiectasia type 1 (HHT1) a vascular disorder characterized by localized vascular dysplasia and a tendency towards arteriovenous malformations. Mice expressing a single CD105 allele develop external signs of disease similar to human HHT1, supporting the haploinsufficiency model for HHT1. Mice lacking endoglin die from defective angiogenesis characterized by failure of vascular smooth muscle investment of embryonic blood vessels, suggesting a defect in vascular smooth muscle cell development. Microvessel density (MVD) has been reported to be an independent prognostic indicator of outcome in a variety of human malignancies, with increased MVD correlating with shorter overall and relapse-free survival rates. The MVD counts using anti-CD105 antibody significantly correlated with overall and disease-free survival. | | | Catalog # | C2446-52 | | Applications | Suitable for use in ELISA (as coating and detection antibody), Immunoprecipitation, Western Blot, Flow Cytometry and Immunohistochemistry. Not Suitable for paraffin sections or for inhibition of biological activity. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Frozen): 1:25 | | Flow Cytometry: 1:25 | | Western Blot: 1:25 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6A517 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, containing 0.02% sodium azide and 0.1% BSA. | | Purity | Purified IgG | | Immunogen | HUVEC | | Specificity | Reacts with human CD105 (Endoglin). This clone and an anti-CD34 monoclonal antibody have been successfully used to quantify MVD in human breast carcinoma. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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