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Anti -CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1, INCAM-110) (Biotin)
Anti -CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1, INCAM-110) (Biotin)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
E B IH FC |
|
| CD106, also known as INCAM-1, is a 100-110kD vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine-activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages and bone marrow stromal cells. Endothelial CD106 binds the integrins alpha4beta1 (CD49d/CD29, VLA-4) and alpha4beta7 and contributes to extravasation of lymphocytes, monocytes, basophils and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the beta2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development. This antibody inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium.1-4 | | | Catalog # | C2446-71D | | Applications | Suitable for use in ELISA, Flow Cytometry, Immunohistochemistry (frozen sections) and Western Blot. Other applications have not been tested. | | Recommended Dilution | Flow Cytometry: 10ul/10e6 cells | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 5K267 | | Host | Mouse | | Source | Human | | Concentration | ~100tests/ml | | Form | Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to Biotin. | | Purity | Purified | | Specificity | Recognizes human CD106/VCAM-1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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