Anti -CD106 (DKFZp779G2333, INCAM 100, INCAM-100, L1CAM, MGC99561, Vascular Cell Adhesion
Molecule 1, VCAM 1, VCAM-1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
IH FC IF |
|
| CD106, otherwise known as VCAM-1 (vascular adhesion molecule 1), a 110kDa inducible type I transmembrane glycoprotein and member of the immunoglobulin supergene family, which is predominantly expressed on vascular endothelium, and also on bone marrow stromal cells, follicular dendritic cells and some macrophages. CD106 interacts with the lymphocyte homing receptor VLA-4 (alpha4 beta1 integrin) and LPAM-1 (alpha4 beta7 integrin) and mediates leukocyte-endothelial cell adhesion and signal transduction. Expression of CD106 is upregulated following cytokine activation, and endothelial CD106 plays a role in the extravasation of leukocytes from blood vessels during inflammation. | | | Catalog # | C2446-71K | | Applications | Suitable for use in Immunofluorescence, Flow Cytometry, Immunohistochemistry (frozen). Other applications not tested. | | Recommended Dilution | Flow Cytometry: Neat-1:25 10ul labels 1x10e6 cells in 100ul. | | Optimal dilutions to be determined by the researcher. | | Recommended Secondary Antibodies Goat Anti Mouse IgG IgA IgM Alk. Phos., HRP HuCAL Anti Mouse IgG1 HRP Sheep Anti Mouse IgG (H&L) Biotin, FITC Goat Anti Mouse IgG (H&L) Alk. Phos., DyLight™488, DyLight™549, DyLight™649, FITC, HRP Rabbit Anti Mouse IgG RPE Goat Anti Mouse IgG (Fc) FITC, HRP Rabbit Anti Mouse IgG HRP Goat Anti Mouse IgG FITC Goat Anti Mouse IgG RPE Goat Anti Mouse IgG HRP Rabbit Anti Mouse IgG FITC | | Recommended Negative Controls Mouse IgG1 NEGATIVE CONTROL | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 9F89 | | Host | Mouse | | Source | Rat | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Rat CD106-transfected L5178Y cells. | | Specificity | Recognizes rat CD106, otherwise known as VCAM-1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
