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You are here:Home » Antibodies » Abs to CD Markers » Anti -CD115 (c-fms, Fms, CSF-1R, M-CSFR)

Anti -CD115 (c-fms, Fms, CSF-1R, M-CSFR)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH IC
CD115, also known as c-fms, macrophage colony stimulating factor receptor (M-CSFR), or CSF-1R, exists in immature (gp130c-fms) and mature (gp150c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain.
Catalog #C2447-52B
ApplicationsSuitable for use in Immunocytochemistry and Immunohistochemistry. Other applications have not been tested.
Recommended DilutionImmunocytochemistry: Fresh, frozen or formalin-fixed paraffin- embedded tissue sections.
Immunohistochemistry: Formalin-fixed paraffin-embedded tissue sections. Antigen retrieval with heating in citrate buffer recommended.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceFeline
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 10mM sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide: Ser-Leu-Pro-Arg-Leu-Lys-Arg-Ser-Glu-Ser-Gly- Arg-Tyr selected from the external domain of the feline v-fms sequence (amino acids 399-411).
SpecificityRecognizes human c-fms oncoprotein. Species crossreactivity: mouse macrophages.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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