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Anti -CD115 (c-fms, Fms, CSF-1R, M-CSFR)
Anti -CD115 (c-fms, Fms, CSF-1R, M-CSFR)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH IC |
|
| CD115, also known as c-fms, macrophage colony stimulating factor receptor (M-CSFR), or CSF-1R, exists in immature (gp130c-fms) and mature (gp150c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain. | | | Catalog # | C2447-52B | | Applications | Suitable for use in Immunocytochemistry and Immunohistochemistry. Other applications have not been tested. | | Recommended Dilution | Immunocytochemistry: Fresh, frozen or formalin-fixed paraffin- embedded tissue sections. | | Immunohistochemistry: Formalin-fixed paraffin-embedded tissue sections. Antigen retrieval with heating in citrate buffer recommended. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Feline | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 10mM sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic peptide: Ser-Leu-Pro-Arg-Leu-Lys-Arg-Ser-Glu-Ser-Gly- Arg-Tyr selected from the external domain of the feline v-fms sequence (amino acids 399-411). | | Specificity | Recognizes human c-fms oncoprotein. Species crossreactivity: mouse macrophages. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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