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You are here:Home » Antibodies » Antibodies-CD Markers » Anti -CD126 (Interleukin 6 Receptor, IL-6R)

Anti -CD126 (Interleukin 6 Receptor, IL-6R)


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Clone Host Grade Applications
Monoclonal Mouse Highly Purified E IP IH FC
The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component speci c to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low af nity binding sites for IL-6, is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity.
Catalog #C2464-01
ApplicationsSuitable for use in Flow Cytometry, Immunohistochemistry, ELISA, Immunoprecipitation and Inhibition assays. Other applications not tested.
Recommended DilutionsFlow Cytometry: 1:50 Use 10ul to label 10e6 cells in 100ul.
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
HybridomaSpleen cellls from immunized BALB/c (Iffa Credo) mice were fused with the X63/Ag.8653 mouse myeloma cell line.
Recommended Secondary ReagentsI1904-66A IgG, F(abí)2, X-Adsorbed (FITC)
Recommended Negative ControlsI1904-78R: IgG1 Murine Negative Control
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No3H1836
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide. Removal of sodium azide is recommended prior to use in functional assays.
PurityPurified by Ion Exchange chromatography.
ImmunogenCHO cells transfected with cDNA of the IL-6 receptor.
SpecificityRecognizes soluble and membranous human IL-6R. This antibody has been shown to inhibit IL-6 mediated proliferation of XG-1 cells. It partially blocks binding of IL-6 to its receptor.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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