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You are here:Home » Molecular Biology » MB-CD Markers » CD134 Ligand CD8a, Fusion Protein

CD134 Ligand CD8a, Fusion Protein

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Specifications

Human CD134L (OX-40 Ligand) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells.  CD134L binds to CD134 present on  activated T cells, providing a costimulatory signal (1). This pathway seems to be more effective for costimulation of CD4+ helper T cells than for CD8+ effector T cells (4). Blockade of this interaction in mouse abrogated immunological effects in several models of  immflamation and rejection (5,6,7,8).
Catalog #C2515-40F
Functional Application CD134L-muCD8 fusion protein binds to CD134 positive cells in Flow cytometry.
Human CD134L-muCD8 Fusion Protein*
Molecular Structure A soluble molecule consisting of the extracellular domain (132 aa) of human CD134L fused to the extracellular domain (167aa) of murine CD8 alpha.
Transfectant Cell Line CHO
ApplicationsSuitable for use in ELISA, Flow cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: protein binds to CD134 positive cells
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight34.1kD
SourceCHO cells
PurityPurified by affinity chromatography.
Concentration~0.5mg/ml
FormSupplied as a liquid in 50mM sodium phosphate, 100mM Potassium chloride, 150mM sodium chloride, pH 7.5, 0.5 mg/ml Gentamicin Sulfate.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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