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Specifications

Human CD137 Ligand is a type II transmembrane protein constitutively expressed by monocytes, B cells and neuroblastoma cells (1). Binding of CD137 (4-1BB) to CD137L induces monocyte activation (2). Human CD137L-muCD8 binds to CD137 on human cells and is blocked by CD137-huIg fusion protein.
Catalog #	C2548-38A
Functional Application	Human CD137L-muCD8 binds to CD137 and blocks binding of anti-CD137 monoclonal antibody.
	Human CD137L-muCD8 Fusion Protein*
Molecular Structure	A soluble fusion protein consisting of the extracellular domain (184aa) of human CD137 Ligand fused to the extracellular domain (167aa) of murine CD8 alpha.
Transfectant Cell Line	CHO
Applications	Suitable for use in ELISA, Flow cytometry. Other applications not tested.
	Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight	38.2kD
Source	CHO cells
Purity	Purified by affinity chromatography.
Concentration	~0.5mg/ml
Form	Supplied as a liquid in FBS, 50mM Tris 150mM NaCl 1mM Spermidine pH 8.0, 0.2% BSA, 0.5 mg/ml Gentamicin Sulfate.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.