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You are here:Home » Molecular Biology » MB-CD Markers » CD146, Recombinant, Human (Mucin 18, MUC18 Glycoprotein, Melanoma Associated Antigen A32, S-endo 1 Endothelial Associated Antigen, Melanoma Adhesion Molecule Mel-CM)

CD146, Recombinant, Human (Mucin 18, MUC18 Glycoprotein, Melanoma Associated Antigen A32,
S-endo 1 Endothelial Associated Antigen, Melanoma Adhesion Molecule Mel-CM)

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Specifications

CD146 (aa433-647) belongs to the immunoglobulin supergene family with five immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions. CD146 has a molecular size of 130kD in its reduced form (118kD unreduced), and N linked glycosylation accounts for fifty percent of the apparent molecular weight. In some cells the molecule carries a sulfate 3 glucuronyl moiety.
Catalog #C2548-78R
ApplicationsSuitable for use in ELISA, Western Blot and Inhibition assays. Other applications not tested.
Recommended Dilutions Optimal dilutions to be detrmined by the researcher.
Storage and StabilityFor long-term storage, aliquot and stoe at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight47kD
SourceE. coli
PurityPurified by proprietary chromatographic techniques. On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 47kD
Concentration~0.1mg/ml
FormSupplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA, 20% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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