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CD146, Recombinant, Human (Mucin 18, MUC18 Glycoprotein, Melanoma Associated Antigen A32, S-endo 1 Endothelial Associated Antigen, Melanoma Adhesion Molecule Mel-CM)
CD146, Recombinant, Human (Mucin 18, MUC18 Glycoprotein, Melanoma Associated Antigen A32,
S-endo 1 Endothelial Associated Antigen, Melanoma Adhesion Molecule Mel-CM)
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| CD146 (aa433-647) belongs to the immunoglobulin supergene family with five immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions. CD146 has a molecular size of 130kD in its reduced form (118kD unreduced), and N linked glycosylation accounts for fifty percent of the apparent molecular weight. In some cells the molecule carries a sulfate 3 glucuronyl moiety. | | | Catalog # | C2548-78R | | Applications | Suitable for use in ELISA, Western Blot and Inhibition assays. Other applications not tested. | | Recommended Dilutions | Optimal dilutions to be detrmined by the researcher. | | Storage and Stability | For long-term storage, aliquot and stoe at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 47kD | | Source | E. coli | | Purity | Purified by proprietary chromatographic techniques. On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 47kD | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA, 20% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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