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You are here:Home » Molecular Biology » MB-CD Markers » CD152 IgG2a Fc, Fusion Protein (CTLA4, Cytolytic T-lymphocyte-associated Antigen 4)

CD152 IgG2a Fc, Fusion Protein (CTLA4, Cytolytic T-lymphocyte-associated Antigen 4)


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Immune response mediated by T cells can be characterized to functionally proceed as follows: antigen recognition by the T cell receptor, activation through costimulation, effector activities to eliminate antigen and finally down regulation. Human CD152 is a cell surface glycoprotein expressed at low levels on activated T cells. CD152 is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2) and appears to function as a negative regulator of T cell activation. Therefore, CD152 may be an important player in down regulating T cell mediated immune responses. The CD152 Ig fusion protein has biological activity and binds with high affinity to human or mouse CD80 (B7-1) and CD86 (B7-2). CD152 Ig will block the binding of anti-CD80 (B7-1) and anti-CD86 (B7-2) monoclonal antibodies.
Catalog #C2548-83V
Functional Application CD152 Ig binds with high affinity to human or mouse CD80 (B7-1) and CD86 (B7-2) (4, 5).  CD152 Ig blocks the binding of anti-CD80 (B7-1) and anti-CD86 (B7-2) mAbs.
Human CD152(CTLA-4) muIg Fusion Protein*(also binds to mouse CD80/CD86)
Molecular Structure A soluble 110kD dimeric fusion protein consisting of the extracellular (125aa) domain of human CD152 (CTLA-4) fused to murine IgG2a Fc
Transfectant Cell Line BHK
ApplicationsSuitable for use in ELISA, Flow Cytometry, and Antibody Blocking. Other applications not tested.
Recommended Dilution Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight40.1kD
SourceBHK cells
PurityPurified by Protein A chromatography. Purity was tested by SDS-PAGE and found to be >95% with <1% Bovine Immunoglobulin.
FormSupplied as a liquid in 50mM sodium phosphate pH 7.5, 100mM potassium chloride, and 150mM sodium chloride, 0.5mg/ml Gentamicin Sulfate.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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