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CD152 IgG2a Fc, Fusion Protein (CTLA4, Cytolytic T-lymphocyte-associated Antigen 4) (PE)
CD152 IgG2a Fc, Fusion Protein (CTLA4, Cytolytic T-lymphocyte-associated Antigen 4) (PE)
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| Immune response mediated by T cells can be characterized to functionally proceed as follows: antigen recognition by the T cell receptor, activation through costimulation, effector activities to eliminate antigen and finally down regulation. Human CD152 is a cell surface glycoprotein expressed at low levels on activated T cells. CD152 is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2) and appears to function as a negative regulator of T cell activation. Therefore, CD152 may be an important player in down regulating T cell mediated immune responses. The CD152 Ig fusion protein has biological activity and binds with high affinity to human or mouse CD80 (B7-1) and CD86 (B7-2). CD152 Ig will block the binding of anti-CD80 (B7-1) and anti-CD86 (B7-2) monoclonal antibodies. | | | Catalog # | C2548-83V3 | | Functional Application | CD152 Ig binds with high affinity to human or mouse CD80 (B7-1) and CD86 (B7-2)(4, 5). CD152 Ig blocks the binding of anti-CD80 (B7-1) and anti-CD86 (B7-2) mAbs. | | Human CD152(CTLA-4)-muIg/R-PE Fusion Protein*(also binds to mouse CD80/CD86) | | Molecular Structure | A soluble 110 kd dimeric fusion protein consisting of the extracellular (125aa) domain of human CD152 (CTLA-4) fused to murine IgG2a Fc | | Transfectant Cell Line | BHK | | Applications | Suitable for use in ELISA and Flow cytometry. Other applications not tested. | | Recommended Dilution Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only pror to immediate use. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. | | Molecular Weight | 40.1kD | | Source | BHK cells | | Purity | Purified by Protein A affinity chromatography. | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in 50mM Sodium Phosphate pH 7.5, 500mM Potassium Chloride, 150mM NaCl, 15% Glycerol, 0.2% BSA, 0.04% NaN3. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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