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CD152 IgG2a Fc, Fusion Protein (CTLA4, Cytolytic T-lymphocyte-associated Antigen 4) (Preservative Free)
CD152 IgG2a Fc, Fusion Protein (CTLA4, Cytolytic T-lymphocyte-associated Antigen 4)
(Preservative Free)
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| mmune response mediated by T cells can be characterized to functionally proceed as follows: antigen recognition by the T cell receptor, activation through costimulation, effector activities to eliminate antigen and finally down regulation. Human CD152 is a cell surface glycoprotein expressed at low levels on activated T cells. CD152 is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2) and appears to function as a negative regulator of T cell activation. Therefore, CD152 may be an important player in down regulating T cell mediated immune responses | | | Catalog # | C2548-83VX | | Transfectant Cell Line | BHK | | Applications | Suitable for use in ELISA and Flow Cytometry. Other applications not tested. | | Functional Application | Binds with high affinity to human or mouse CD80 (B7-1) and CD86 (B7-2) (4, 5). Blocks the binding of anti-human CD80 (B7-1) and anti-human CD86 (B7-2) mAbs to recepters on Raji cells. Crossreacts with CD80 and CD86 across a broad range of mammalian species including pig (6). | | Recommended Dilution | Flow Cytometry: 05ug/ml. 80ul of diluted C2548-83VX labels 5x10e5 cultured Raji cells. Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 40.1kD | | Source | BHK cells | | Purity | Purified by Protein A affinity chromatography. (> 95% by SDS-PAGE with <1% bovine immunoglobulin) | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, sterile filtered under aseptic conditions. No preservative added. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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