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You are here:Home » Antibodies » Abs to Receptors, Scavenger » Anti -CD163 (CD163 Antigen, Hemoglobin Scavenger Receptor, M130, M130 Antigen Precursor, Macrophage-associated Antigen, MM130, Scavenger Receptor Cysteine-rich Type 1 Protein M130)

Anti -CD163 (CD163 Antigen, Hemoglobin Scavenger Receptor, M130, M130 Antigen Precursor,
Macrophage-associated Antigen, MM130, Scavenger Receptor Cysteine-rich Type 1 Protein
M130)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH FC
CD163 expressed exclusively on the cell surface of human monocytes and macrophages that predominantly evolve in the late phase of inflammation. The CD163 is a member of the scavenger receptor cysteine-rich superfamily. CD163 is a scavenger receptor for the hemoglobin-haptoglobin complex. The protein expression is markedly induced by glucocorticoids while it is down-regulated by cyclosporin A and by phorbol esters. CD163 is sensitive to ionic detergents and to chloroform/methanol treatment. Positive staining can be observed in the skin (histiocytes), gut, Kupffer cells, few alveolar macrophages, a main population of macrophages in the placenta, varying degrees of macrophages in inflamed tissue, including tumorous tissue depending on the inflammatory stage. Red pulp, but not white pulp macrophages of the spleen, and cortical macrophages of the thymus are detected. Macrophages in the synovialis of patients with rheumatoid arthritis; in alveolar macrophages and in Kupffer cells a double staining can be observed with the monoclonal antibody 25F9 (HM2158) which is not the case in other tissues. The monoclonal antibody RM3/1 is very useful for macrophage phenotyping.
Catalog #C2548-90G
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone NoRM3/1
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide, 0.1% BSA.
PurityPurified by Protein G affinity chromatography.
ImmunogenHuman CD163.
SpecificityRecognizes human CD163 at ~130kD Species Crossreactivity: monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCD163 Molecule


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