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You are here:Home » Antibodies » Abs to Receptors, Scavenger » Anti -CD163 (CD163 Antigen, Hemoglobin Scavenger Receptor, M130, M130 Antigen Precursor, Macrophage-associated Antigen, MM130, Scavenger Receptor Cysteine-rich Type 1 Protein M130)

Anti -CD163 (CD163 Antigen, Hemoglobin Scavenger Receptor, M130, M130 Antigen Precursor,
Macrophage-associated Antigen, MM130, Scavenger Receptor Cysteine-rich Type 1 Protein
M130)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
CD163 was recently identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes (low expression) and tissue macrophages [also known as histiocytes] (high expression). It is a member of the cysteine-rich scavenger receptor superfamily, encoded by a gene localized on human chromosome 12p13.3. Solubilized in plasma, CD163 functions as an anti-inflammatory signal and has many roles in disease processes that range from autoimmune conditions such as rheumatoid arthritis to atherosclerosis. Previous work has shown that the CD163 gene can be regulated by glucocorticoids, IL-10, and other inflammatory modulators, and is highly expressed in inflamed tissues, consistent with its role in the resolution of inflammation.
Catalog #C2548-90H
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Paraffin, frozen): 1:10-1:50. Staining pattern: cytoplasmic, membranous.
Optimal dilutions to be determined by the researcher.
Positive ControlInflamed Tissue
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone NoMRQ-26
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4, carrier protein, sodium azide.
PuritySupernatant
SpecificityRecognizes human CD163.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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