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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -Cdc2 (CDK 1, CDK1, Cdc 2, Cell Divsion Cycle 2 Protein, Cell division control protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2 to M, Cyclin Dependent Kinase 1, DKFZp686L20222, MGC111195, p34 Protein Kinase)

Anti -Cdc2 (CDK 1, CDK1, Cdc 2, Cell Divsion Cycle 2 Protein, Cell division control
protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2
to M, Cyclin Dependent Kinase 1, DKFZp686L20222, MGC111195, p34 Protein Kinase)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH IC
The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
Catalog #C2549-49G
ApplicationsSuitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Paraffin-embedded sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No8J944
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid is PBS. pH 7.4, 15mM sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant full length human Cdc2.
SpecificityRecognizes human Cdc2 Species Crossreactivity: bovine, mink and monkey. Does not crossreact with mouse, rat, Drosophila melanogaster, S. cerevisiae, S. pombe or Xenopus laevis.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCDK 1, CDK1, Cdc 2, Cell Divsion Cycle 2 Protein, Cell division control protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2 to M, Cyclin Dependent Kinase 1, DKFZp686L20222, MGC111195, p34 Protein Kinase


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