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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -CDC2-related Protein Kinase 7 (Cell Division Cycle 2-related Protein Kinase 7, CRK7, Cdc2-related Kinase Arginine/serine-rich, CRKR, CrkRS, Cell Division Protein Kinase 12, Cyclin-dependent Kinase 12, CDK12, hCDK12, KIAA0904)

Anti -CDC2-related Protein Kinase 7 (Cell Division Cycle 2-related Protein Kinase 7, CRK7,
Cdc2-related Kinase Arginine/serine-rich, CRKR, CrkRS, Cell Division Protein Kinase 12,
Cyclin-dependent Kinase 12, CDK12, hCDK12, KIAA0904)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
CRK7 is a CDC2/CDK -type protein kinase. Also known as CRKRS, the protein has an arginine/serine-rich (RS) domain that is found predominantly in splicing factors, and extensive proline-rich regions that match the consensus for SH3 and WW domain binding sites. Anti-CrkRS immunoprecipitates have been shown to phosphorylate the C-terminal domain of RNA polymerase II in vitro. CRK7 has been shown to be expressed ubiquitously. Nuclear staining is seen in some carcinomas (breast, lung, others), this may be because these cells are actively dividing and this gene is associated with cell division. ESTs have been isolated from several tissue libraries, including normal lymph and cancerous bone.
Catalog #C2549-52D
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 6ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman Breast carcinoma
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the internal domain of human CRK7.
SpecificityRecognizes human CRK7.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=2.7.11.22, EC=2.7.11.23


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