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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -CDC25C, CT (Cell Division Cycle 25 Homolog C, Cdc 25C, CDC 25, Dual Specificity Phosphatase Cdc25C, M-phase Inducer Phosphatase 3, MPIP3, PPP1R60)

Anti -CDC25C, CT (Cell Division Cycle 25 Homolog C, Cdc 25C, CDC 25, Dual Specificity
Phosphatase Cdc25C, M-phase Inducer Phosphatase 3, MPIP3, PPP1R60)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP FC
Cdc25C is a tyrosine protein phosphatase required for progression of the cell cycle. Cdc25C activates cell cycle-specific cyclin-dependent kinases (CDKs), including cdc2, via dephosphorylation events. Cdc25C is activated via phosphorylation at Ser216. In response to DNA damage and DNA replicational stress, Chk1 and Chk2 phosphorylate Cdc25C to prevent entry into mitosis.
Catalog #C2560-15B
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Immunoprecipitation. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:10
Western Blot: 1:500
Immunoprecipitation: 1:30
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add glycerol (40-50%) and aliquot. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No6k115
HostRabbit
SourceHuman
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, and 40% glycerol.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to residues in C-terminus of human Cdc25C.
SpecificityRecognizes human Cdc25C. Does not cross-react with other MPI phosphatase family members. Mol. Wt.: 54kD
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCell Division Cycle 25C Protein, EC=3.1.3.48, Mitosis Inducer CDC25


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