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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -Cdc37 (S. cerevisiae hypothetical protein CDC37, CDC37 cell division cycle 37 homolog, Cdc37, Hsp90 chaperone protein kinase targeting subunit, Hsp90 p50Cdc37, co chaperone Cdc37, p50Cdc37)

Anti -Cdc37 (S. cerevisiae hypothetical protein CDC37, CDC37 cell division cycle 37
homolog, Cdc37, Hsp90 chaperone protein kinase targeting subunit, Hsp90 p50Cdc37, co
chaperone Cdc37, p50Cdc37)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Serum B
CDC37 is an important component of the HSP90 chaperone complex (1,2). It was initially identified for its involvement in cell cycle progression and was later found to have a much broader role as a chaperone for a wide variety of kinases and other proteins (1-3). CDC37 protein has an amino-terminal kinase-binding domain followed by a central HSP90 binding domain. It recruits and stabilizes kinases in the HSP90 complex by protecting the newly synthesized kinase peptide chain from degradation and promoting the next step of protein maturation (4,5). CDC37 also suppresses the ATPase activity of HSP90, thereby leading to conformational changes in the complex that preclude target kinase loading (6). CDC37 has been proposed as a therapeutic target because of its important role in multiple kinase pathways involved in proliferation and cancer cell survival, including Raf, Akt, Src, ErbB2 pathways (7,8).
Catalog #C2562-04B
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000. Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1%
Tween-20 at 4°C with gentle shaking, overnight.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No10E15
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied in 10mM sodium HEPES pH 7.5, 150mM NaCl, 100ug/ml BSA and 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to residues surrounding Val367 of human CDC37 protein (KLH-coupled).
SpecificityRecognizes human CDC37 (D28H7). Species crossreactivity: mouse, rat, monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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