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Anti -CDCP1 (CUB Domain-containing Protein 1, Membrane Glycoprotein gp140, Subtractive Immunization M Plus HEp3-associated 135kD Protein, SIMA135, Transmembrane and Associated with Src Kinases, CD318, TRASK, UNQ2486/PRO5773) (PE)
Anti -CDCP1 (CUB Domain-containing Protein 1, Membrane Glycoprotein gp140, Subtractive
Immunization M Plus HEp3-associated 135kD Protein, SIMA135, Transmembrane and Associated
with Src Kinases, CD318, TRASK, UNQ2486/PRO5773) (PE)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
FC |
|
| CDCP1, also known as SIMA135, is a novel 140kD type I transmembrane glycoprotein with three CUB protein-protein interaction domains in its 635aa extracellular region. The 148aa cytoplasmic region contains canonical phosphorylation sites for Src kinase family members and binding sites for SH3 domains. By alternative splicing, a secreted 310aa residue form of CDCP1 also exists. The amino-terminal region of ~265aa of the type I membrane CDCP1 can also be proteolytically cleaved. CDCP1 is found on the surface of epithelial and bone marrow- derived stem cells. The extracellular region of human CDCP1 shares 84% aa identity with that of the mouse protein. | | | Catalog # | C2566-01K | | Applications | Suitable for use in Flow Cytometry. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Absorption | 488nm | | Emission | 565-605nm | | Storage and Stability | May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 12K58 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE). | | Purity | Purified by Protein A/G affinity chromatography. | | Immunogen | Recombinant corresponding to aa33-666 from human CDCP1 expressed in NSO cell line. | | Specificity | Recognizes an epitope at aa370-666 of human CDCP1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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