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You are here:Home » Antibodies » Abs to Cell Division Cycle (CDC) » Anti -CDK11 (Cyclin Dependent Kinase 11, CDK11A, CDK11-p46, CDK11-p58, CDK11-p110, Cell Division Cycle 2-like 1, CDC2L1, Cell Division Cycle 2-like Protein Kinase 2, CDC2L2, CDC2L3, Galactosyltransferase-associated Protein Kinase, MGC131975, PITSLRE, PITSLRE Pr

Anti -CDK11 (Cyclin Dependent Kinase 11, CDK11A, CDK11-p46, CDK11-p58, CDK11-p110, Cell
Division Cycle 2-like 1, CDC2L1, Cell Division Cycle 2-like Protein Kinase 2, CDC2L2,
CDC2L3, Galactosyltransferase-associated Protein Kinase, MGC131975, PITSLRE, PITSLRE Pr

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Three major isoforms of Cdk11 identified are the full length gene product Cdk11p110 and the shorter polypeptides Cdk11p58 and Cdk11p46. Cdk11p110 is a component of RNA polymerase II containing complexes involved in transcriptional regulation, and is implicated in pre-mRNA splicing through interaction with the splicing factor RNPS1 (RNA-binding protein with serine-rich domain 1). Cdk11p58 has been linked with mitosis, cell cycle arrest and apoptosis, and recently implicated as a negative regulator of the androgen receptor (AR) as part of a cyclin D3/ Cdk11p58 complex. Cdk11p46 arises from the cleavage of Cdk11p110 and Cdk11p58 by caspases following the induction of apoptosis, and is linked with apoptotic progression.
Catalog #C2579-15
ApplicationsSuitable for use in Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionImmunoprecipitation: 1ug/mg
Western Blot: 1:10,000-1:30,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in tris-citrate/phosphate, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to an epitope within aa residues 730-780 of human Cdk11 (GeneID 985).
SpecificityRecognizes human Cdk11. Species sequence homology: mouse and xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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