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You are here:Home » Antibodies » Antibodies-Protein Kinase Substrates » Anti -CDKs Substrate, Ser-phosphorylated (KS*P Motif)

Anti -CDKs Substrate, Ser-phosphorylated (KS*P Motif)


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Clone Host Grade Applications
Monoclonal Rabbit Supernatant E B IP
Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases that regulate cell-cycle transitions through their association and subsequent phosphorylation of targets in a strictly ordered fashion. The substrates for CDKs are proline-directed. The consensus amino acid sequence for CDK substrate is (K/R)(S*)PX(K/R), where X denotes any one of the 20 amino acids and S* is the phosphorylation site. Phospho-(Ser) CDKs Substrate antibody C2580-01 recognizes phosphorylated CDK substrates at their consensus motif, providing a powerful tool for CDK target discovery and characterization, as well as HTS drug screening for potential kinase regulators.
Catalog #C2580-01
ApplicationsSuitable for use in Peptide ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionsELISA (peptide): 1:1000
Western Blot: 1:1000
Immunoprecipitation: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol, and <0.02% sodium azide
ImmunogenSynthetic phospho-CDK substrate peptide library. The antibody is formulated from two rabbit monoclones in order to cover a broad range of reactivity.
SpecificityRecognizes phospho-serine in a KS*P motif. Does not crossreact with phospho-threonine or phospho-tyrosine containing peptides/proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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