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You are here:Home » Antibodies » Abs to Protein Kinase Substrates » Anti -CDKs Substrate, Ser-phosphorylated (KS*P Motif)

Anti -CDKs Substrate, Ser-phosphorylated (KS*P Motif)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant E B IP
Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases that regulate cell-cycle transitions through their association and subsequent phosphorylation of targets in a strictly ordered fashion. The substrates for CDKs are proline-directed. The consensus amino acid sequence for CDK substrate is (K/R)(S*)PX(K/R), where X denotes any one of the 20 amino acids and S* is the phosphorylation site. Phospho-(Ser) CDKs Substrate antibody C2580-01 recognizes phosphorylated CDK substrates at their consensus motif, providing a powerful tool for CDK target discovery and characterization, as well as HTS drug screening for potential kinase regulators.
Catalog #C2580-01
ApplicationsSuitable for use in Peptide ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionsELISA (peptide): 1:1000
Western Blot: 1:1000
Immunoprecipitation: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG
HostRabbit
ConcentrationNot determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol, and <0.02% sodium azide
PuritySupernatant
ImmunogenSynthetic phospho-CDK substrate peptide library. The antibody is formulated from two rabbit monoclones in order to cover a broad range of reactivity.
SpecificityRecognizes phospho-serine in a KS*P motif. Does not crossreact with phospho-threonine or phospho-tyrosine containing peptides/proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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