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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -CDR2 (Yo Paraneoplastic Antigen, Cerebellar Degeneration-related Protein (62kD), Cerebellar Degeneration-related Antigen-2 (62kD), Cerebellar Degeneration-related Protein 2, Paraneoplastic Cerebellar Degeneration-associated Antigen, Major Yo Paraneoplasti

Anti -CDR2 (Yo Paraneoplastic Antigen, Cerebellar Degeneration-related Protein (62kD),
Cerebellar Degeneration-related Antigen-2 (62kD), Cerebellar Degeneration-related Protein
2, Paraneoplastic Cerebellar Degeneration-associated Antigen, Major Yo Paraneoplasti

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Using anti-Yo antibodies, three genes have been cloned (CDR 1-3). CDR2 Cerebellar degeneration related protein 2) suppresses the transcriptional activity and DNA binding of nuclear factor-kappa B by an unknown mechanism. The neuron specific expression of CDR2 is regulated by a post-transcriptional mechanism.
Catalog #C2581-01B
CDR2 is an onconeuronal antigen; i.e. an antigen that is expressed by systemic tumors and elicits an immune response that may develop into an autoimmune neuronal degeneration. Paraneoplastic cerebellar degeneration (PCD) is a disorder in which breast or ovarian tumors express CDR2, which normally is expressed in cerebellar Purkinje neurons
ApplicationsSuitable for ELISA, Immunohistochemistry and Western Blot. Other Applications not tested.
Recommended DilutionWester Blot: 2ug/ml; Positive Control: HeLa whole cell lysates. A band is seen at ~51kD.
Immunohistochemistry: 5-10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as liquid in Tris-citrate/phosphate, pH 7- 8, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide made to a C-terminal region of the human CDR2.
SpecificityRecognizes human CDR2 Species Crossreactivity: Bovine, mouse, primate.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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