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You are here:Home » Antibodies » Antibodies-Cancer Markers » Anti -CEACAM 1 (Carcinoembryonic Antigen Related Cell Adhesion Molecule, BGP)

Anti -CEACAM 1 (Carcinoembryonic Antigen Related Cell Adhesion Molecule, BGP)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH FC
CEACAM1 (BGP) belongs to the carcinoembryonic antigen
(CEA) gene family. It is expressed on cells of epithelial and myeloid origin. CEACAM1 expression is downregulated in many tumors indicating a tumor - suppressive function. The antitumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of antiangiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the iimmunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM.
Catalog #C2589-53
ApplicationsSuitable for use in Flow Cytometry, ELISA and Immunohistochemistry. It is expected that the antibody will be suited for all applications where recognition of the native protein is required. Other applications not tested.
Recommended DilutionELISA: 1:200-1:400
Immunohistochemistry (Frozen): 10ug/ml
Flow Cytometry: 1.2ug/10e6 cells
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No5E510
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein G affinity chromatography.
ImmunogenGenerated by genetic immunization with cDNA encoding the extracellular region of human CEACAM1-A2.
SpecificityRecognizes human CEACAM1(biliary glycoprotein I, BGP,CD66a) transiently expressed on the cell surface of transfected BOSC cells as well as the naturally expressed protein. As the A2 domain is unique to CEACAM1, C2589-53 can be used to distinguish CEACAM1 from all other CEACAM.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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