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You are here:Home » Antibodies » Abs to Transcription Factors, Homeobox (HOX) » Anti -CDX2 (CDX2, Caudal Type Homeobox Transcription Factor 2, HGNC:1806, CDX-3, CDX3)

Anti -CDX2 (CDX2, Caudal Type Homeobox Transcription Factor 2, HGNC:1806, CDX-3, CDX3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
CDX2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20.
Catalog #C2589-57
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Paraffin): 1:25-1:50. ABC method; incubation period of 60 min at RT. FFPE tissue sections require high temperature antigen unmasking with 1mM EDTA buffer, pH 8.0 prior to immunostaining.
Immunohistochemistry: 1:10-1:2000
Optimal dilutions to be determined by the researcher.
Recommended Positive Control Colon cancer
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No8J980
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid, 0.1% sodium azide.
PurityTissue culture supernatant
ImmunogenProkaryotic recombinant protein corresponding to the 180 amino acid near the N-terminal region of the human CDX2 molecule.
Cellular LocalizationNuclear
SpecificityRecognizes human CDX2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCDX2, Caudal Type Homeobox Transcription Factor 2, HGNC:1806, CDX-3, CDX3


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