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You are here:Home » Antibodies » Abs to Transcription Factors, Homeobox (HOX) » Anti -CDX2 (Homeobox Protein CDX-2, CDX-3, Caudal-type Homeobox Protein 2, CDX3)

Anti -CDX2 (Homeobox Protein CDX-2, CDX-3, Caudal-type Homeobox Protein 2, CDX3)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
CDX2 is a caudal-type homeobox domain-containing transcription factor, important in the development and differentiation of the intestines.It is a part of a regulatory network that orchestrates a developmental program of proliferation, morphogenesis, and gene expression in the intestinal epithelium. It has 311aa and its homeodomain is a 60-aamotif containing a sequence-specific DNA binding domain. The human CDX2 gene is localized to chromosome 13q12-13. The protein has been shown to positively regulate genes expressed in the small intestine such as sucraseisomaltase, lactase and phospholipase A. CDX2 has been implicated in disorders involving abnormal intestinal differentiation and neoplasia. It is also a sensitive and specific marker for colorectal adenocarcinoma, although its expression is decreased among higher grade and stage tumors, and it is not invariably present in metastases from positive primaries.
Catalog #C2589-57A
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50
Optimal dilutions to be determined by the researcher.
Positive ControlColon cancer
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11E125
HostMouse
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
PuritySupernatant
ImmunogenProkaryotic recombinant corresponding to 180aa N-terminal region of the human CDX2 molecule. Cellular Localization: Nuclear.
SpecificityRecognizes human CDX2. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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