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Anti -CEACAM 1,5,6,8 (Carcinoembryonic Antigen Related Cell Adhesion Molecule)
Anti -CEACAM 1,5,6,8 (Carcinoembryonic Antigen Related Cell Adhesion Molecule)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH FC |
|
| CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leukocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria. | | | Catalog # | C2589-62A | | Application(s) | | | ELISA | | Flow Cytometry: BOSC23 cells transiently transfected with a CEACAM5 expression vector. | | Immunohistochemistry (frozen sections) | | Western Blot. | | Optimal conditions must be determined individually for each application. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 6D307 | | Host | Mouse | | Source | Human | | Concentration | 1mg/ml | | Form | Liquid. Protein G affinity purified antibody in PBS, pH 7.2, containing 0.01% sodium azide. | | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | CEACAM5 (CEA) partially purified from a perchloric acid extract from liver metastases of colonic tumors. | | Specificity | Recognizes human CEACAM1, 5, 6 and 8. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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