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You are here:Home » Antibodies » Abs to Cancer Markers » Anti -CEACAM 7 (Carcinoembryonic Antigen Related Cell Adhesion Molecule)

Anti -CEACAM 7 (Carcinoembryonic Antigen Related Cell Adhesion Molecule)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH FC
CEA-related cell adhesion molecule 7 (CEACAM7, CGM2) belongs to the carcinoembryonic antigen (CEA) family (1). It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells adult colon and on a small epithelial cell population in pancreatic ducts (2). CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon (2). Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constantlike A domain.
Catalog #C2589-81
ApplicationsSuitable for use in Flow Cytometry, ELISA and Immunohistochemistry. It is expected that the antibody will be suited for all applications where recognition of the native protein is required. Other applications not tested.
Recommended DilutionImmunohistochemistry: Frozen.
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No5E513
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide BEFORE THE ADDITION OF GLYCEROL TO 40%.
PurityPurified by Protein G affinity chromatography.
ImmunogenGenerated by immunization of BALB/c mice with a CEACAM7/Fc fusion protein (2).
SpecificityRecognizes exclusively CEACAM7 transiently expressed on the cell surface of transfected BOSC23 cells. Can be used to distinguish CEACAM7 from all other CEACAM and probably all pregnancy-specific glycoprotein molecules, namely CEACAM1, CEACAM3, CEACAM4, CEACAM6, CEACAM7, CEACAM8 and PSG1 based on its reactivity pattern with stable and transiently transfected mammalian cells expressing individual CEA family members.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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