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You are here:Home » Antibodies » Abs to Centromeres » Anti -CENP-A (Centromere Protein A)

Anti -CENP-A (Centromere Protein A)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH IC
Centromere protein A (CENP-A) is a 17-19kD centromere-specific histone variant that is 62% identical to the carboxy-terminal domain of histone H3. In the presence of DNA CENP-A forms an octameric complex with histones H4, H2A, and H2B. CENP-A defines active centromere regions by forming centromere-specific nucleosomes on which kinetochores are assembled. CENP-A is specifically located to the inner plate of the kinetochore and it is essential for kinetochore targeting of CENP-C and other kinetochore components. CENP-A is required for nucleosomal packaging of centromeric DNA at interphase.
Catalog #C2615-10
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1ug/ml
Immunohistochemistry: 5ug/ml
Immunocytochemistry: 10ug/ml
Optimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No4E43
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 50% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to a portion of human CENP-A.
SpecificityRecognizes human CENP-A (~18kD).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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