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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B IH IC

Centromere protein A (CENP-A) is a 17-19kD centromere-specific histone variant that is 62% identical to the carboxy-terminal domain of histone H3. In the presence of DNA CENP-A forms an octameric complex with histones H4, H2A, and H2B. CENP-A defines active centromere regions by forming centromere-specific nucleosomes on which kinetochores are assembled. CENP-A is specifically located to the inner plate of the kinetochore and it is essential for kinetochore targeting of CENP-C and other kinetochore components. CENP-A is required for nucleosomal packaging of centromeric DNA at interphase.
Catalog #	C2615-10
Applications	Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended Dilutions	Western Blot: 1ug/ml
	Immunohistochemistry: 5ug/ml
	Immunocytochemistry: 10ug/ml
	Optimal dilutions to be determined by researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	4E43
Host	Mouse
Source	Human
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 50% glycerol.
Purity	Purified by Protein A affinity chromatography.
Immunogen	Synthetic peptide corresponding to a portion of human CENP-A.
Specificity	Recognizes human CENP-A (~18kD).
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.