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You are here:Home » Antibodies » Abs to Centromeres » Anti -CENP-F (Centromere protein F , CENPF, centromere protein F (350/400kD, mitosin), CENF, PRO1779, mitosin, AH antigen, CENP-F kinetochore protein, centromere protein F (400kD), cell-cycle-dependent 350K nuclear protein)

Anti -CENP-F (Centromere protein F , CENPF, centromere protein F (350/400kD, mitosin),
CENF, PRO1779, mitosin, AH antigen, CENP-F kinetochore protein, centromere protein F
(400kD), cell-cycle-dependent 350K nuclear protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
The kinetophore is a macromolecular structure that is associated with the centromeres of chromosomes and is responsible for establishing and maintaining the connections with the microtubules of the mitotic spindle. The proteins that reside within the chromosomal domain fall into two broad classes: those that associate with the centromere throughout the cell cycle and those that are found at the centromere in a cell cycle specific manner. Members of the first class include CENP-A, CENP-B, and CENP-C. The members of the second class include several ubiquitous cellular proteins such as calmodulin, tubulin, dynein and p34 cdc2 and also CENP-E and CENP-F. CENP-F appears to be the earliest member to interact with the centromere-kinetochore complex. CENP-F also shows a cell-cycle distribution that is both temporally regulated and diverse in terms of the structural components it localizes to and therefore may play a role in several mitotic events. (1-3)
Catalog #C2615-20
Cellular LocalizationAs cells progress through S phase, weak nuclear staining is observed. In G2 phase, very bright CENP-F staining is detected uniformly throughout the nucleus but excluded from the nucleoli.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1 mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 50% glycerol, 0.1% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenA bacterial fusion protein from the C-terminus of CENP-F.
SpecificitySpecific for human CENP-F.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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