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You are here:Home » Antibodies » Abs to Nuclear Proteins » Anti -CENTB1 (Arf-GAP with Coiled-coil, ANK Repeat and PH Domain-containing Protein 1, Centaurin-beta-1, Cnt-b1, ACAP1, KIAA0050)

Anti -CENTB1 (Arf-GAP with Coiled-coil, ANK Repeat and PH Domain-containing Protein 1,
Centaurin-beta-1, Cnt-b1, ACAP1, KIAA0050)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
ACAP1, also known as Centaurin-beta-1 (CENTB1), is a 740aa containing transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain and a PH domain that binds to phospholipids. ACAP1, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6), is required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. It mediates CENTB1-binding to phosphatidylinositol 3,5-bisphosphate (PIP2) or phosphatidylinositol 3,4,5-trisphosphate (PIP3) containing membranes. Along with ACAP2, ACAP1 is recruited to platelet-derived growth factor (PDGF) induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, while over expression inhibited ruffle formation. It is widely expressed in most tissues with high expression in lung and spleen and low expression in heart, kidney, liver and pancreas.
Catalog #C2617-02E1
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlK562 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa520-560 of human ACAP1.
SpecificityRecognizes human CENTB1. Species sequence homology: mouse and bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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