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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Ceramide

Anti -Ceramide

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified E IH IC FC
Ceramides are a family of lipid molecules. A ceramide is composed of sphingosine and a fatty acid. Ceramides are found in high concentrations within the cell membrane of cells. They are one of the component lipids that make up sphingomyelin, one of the major lipids in the lipid bilayer. For years, it was assumed that ceramides and other sphingolipids found in the bilayer cell membrane were purely structural elements. This is now known to be not completely true. Ceramide can actually act as a signaling molecule. The most well-known functions of ceramides as cellular signals include regulating the differentiation, proliferation, programmed cell death (PCD), and apoptosis (Type I PCD) of cells.
Catalog #C2777-95
ApplicationsSuitable for use in ELISA, Flow Cytometry, Immunocytochemistry and Immunohistochemistry. Other applications not tested.
Recommended DilutionsELISA: 1:10
Flow Cytometry: 20ul/test
Immunohistochemistry: 1:10
Optimal dilutions to be determined by the researher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM
Clone No6D311
HostMouse
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.09% sodium azide.
PurityPurified by gel filtration on sephacryl S-300.
ImmunogenCeramide (sphingosine-[trans-D-erythro-2-amino-4-octadecene-1,3-diol]), conjugated to BSA.
SpecificityRecognizes C16- and C24-ceramide, dihydroceramide, sphingomyelin and phosphatidylcholine in highly artificial lipid overlay test systems. Under more physiological in vitro conditions highly specific for ceramide and does not crossreact with sphingomyelin, cholesterol or other phospholipids. Species Crossreactivity: rat, goat, sheep, canine, porcine and monkey
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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