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Specifications

Isolated from Cercosporidium henningsii, cercosporamide was originally identified as a host-selective phytotoxin and broad spectrum antifungal agent. More recently cercosporamide was shown to inhibit a cell wall integrity pathway mediated through a serine/threonine protein kinase, Pkc1, that is central to cell wall biosynthesis. It is both potent (IC50 < 50nM) and selective for Pkc1 kinase inhibition.
Catalog #	C2780-40
Source	Cercosporamide
Molecular Weight	~331.3
Solubility	Soluble in ethanol, methanol, DMF or DMSO.
Storage and Stability	Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	131436-22-1
Molecular Formula	C16H13NO7
Molecular Weight	331.3
Source	Cercosporidium sp. MST-FP1899
Purity	95% by HPLC
Form	Supplied as a dark tan lyophilisate.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.