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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Cerebellin-1 (cerebellin 1 precursor , Precerebellin, CBLN1)

Anti -Cerebellin-1 (cerebellin 1 precursor , Precerebellin, CBLN1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Cerebellin-1, known also as CBLN1, Precerebellin or Cerebellin precursor, is a secreted membrane protein with a predicted molecular weight of 21kD. Cerebellin 1 is required for synapse integrity and synaptic plasticity and for the ER export and secretion of CBLN3. Cerebellin 1 exerts neuromodulatory functions including directly stimulating norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. Research indicates that Cerebellin 1 may also be involved in a wider range of functions than have been so far demonstrated.
Catalog #C2790-50B
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 2-4ug/ml
Immunohistochemistry (paraffin): 10ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman prostate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to a 15aa sequence from near the centre of human cerebellin 1.
SpecificityRecognizes human Cerebellin-1 at ~21KD. Species Cross Reactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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