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You are here:Home » Biochemicals » Biochem-Antibiotics » Cerulenin (Helicocerin, NSC 116069, 2,3-Epoxy-4-oxo-7,10-dodecadienamide)

Cerulenin (Helicocerin, NSC 116069, 2,3-Epoxy-4-oxo-7,10-dodecadienamide)

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Specifications

Cerulenin is an epoxy fatty acid amide isolated from the fungus Cephalosporium caerulens and identified as an antifungal in the 1960s. Over the past 40 years cerulenin has found broad application in lipid biochemistry as an inhibitor fatty acid and sterol biosynthesis. Cerulenin binds to B-keto-acyl-ACP synthase blocking the interaction of malonyl CoA. Cerulenin is also an inhibitor of bacterial fatty acid synthesis acting on the FabH, FabB and FabF condensation enzymes. Cerulenin stimulates fatty acid oxidation and inhibits HMG-CoA synthetase activity.
Catalog #C2890
Apperance Off-white powder
Solubility Soluble in DMSO, methanol or ethanol. Slightly soluble in water.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO, methanol or ethanol. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number17397-89-6
Molecular FormulaC12H17NO3
Molecular Weight223.3
Purity~98%
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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