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Anti -Ceruloplasmin (Cp, Ferroxidase, Iron (II) Oxygen Oxidoreductase)
Anti -Ceruloplasmin (Cp, Ferroxidase, Iron (II) Oxygen Oxidoreductase)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Sheep |
Purified |
B |
|
| Caeruloplasmin is a copper-binding plasma glycoprotein consisting of a single polypeptide chain. It has a molecular weight of 132kDa and occurs in plasma at a concentration of 150-500 mg/L.Although the physiological functions of Caeruloplasmin are not fully understood it is implicated in a number of possible functions. 95% of plasma copper is bound to Caeruloplasmin, implying some involvement in copper transport. Caeruloplasmin has been described as both an oxidant and an antioxidant, its exact role or roles in this respect are not clear. Plasma levels of Caeruloplasmin are elevated after inflammation and trauma and it is therefore classified as an acute phase protein. The measurement of Caeruloplasmin in plasma is useful in the diagnosis of Wilson?s disease, where levels are greatly reduced. Caeruloplasmin is extremely labile in plasma and rapidly degrades to 115kDa and 19kDa fragments. The age of plasma samples should therefore be taken into account when interpreting immunological analysis of caeruloplasmin. | | | Catalog # | C2900-01D | | Applications | Suitable for use in Western Blot, RID and Rocket IEP. Other applications not tested. | | Recommended Dilutions | RID: 2ul antiserum/cm | | Rocket IEP: 2ul antiserum/cm | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Sheep | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in GBS, pH 7.4, 0.1% EACA, 0.01% benzamidine, 1mM EDTA, 0.1% sodium azide. | | Purity | Purified | | Immunogen | Human caeruloplasmin purified from plasma, shown to be pure by SDS-PAGE. Cellular Localiztion: Secreted | | Specificity | Recognizes human Ceruloplasmin. Species Crossreactivity: rat, equine and mouse. Does not crossreact with rabbit, bovine, canine, feline, guinea pig or chicken. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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