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You are here:Home » Antibodies » Abs to Enzymes, Acyltransferase » Anti -CES1 (Carboxylesterase 1, Acyl Coenzyme A:Cholesterol Acyltransferase, ACAT, Brain Carboxylesterase hBr1, CEH, Egasyn, HMSE, HMSE1, Liver Carboxylesterase 1, MGC117365, Monocyte/macrophage Serine Esterase 1, PCE-1, Serine Esterase 1, SES1, Triacylglycerol

Anti -CES1 (Carboxylesterase 1, Acyl Coenzyme A:Cholesterol Acyltransferase, ACAT, Brain
Carboxylesterase hBr1, CEH, Egasyn, HMSE, HMSE1, Liver Carboxylesterase 1, MGC117365,
Monocyte/macrophage Serine Esterase 1, PCE-1, Serine Esterase 1, SES1, Triacylglycerol

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP
Carboxylesterase 1 is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds (1, 2). They have broad substrate specificity ranging from small molecule esters such as phenylester to long chain fatty acid esters and thioesters. They play a major role as determinants of pharmacokinetic behavior for most therapeutic agents containing an ester. By de-esterification, they can activate or inactivate the agents. They also participate in detoxification of drugs such as cocaine and heroin in serum and liver. The resulting de-esterified metabolites are secreted out in urine. They can also detoxify organophosphate and carbamate analogues used in agrochemicals or chemical nerve agents, such as malathion, sarin, tabun, and VX. In addition to the hydrolytic activity, they can perform transesterification, a reaction important for cholesterol homeostasis. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. CES-1 shares the serine hydrolase fold observed in other esterases (3). CES-1 possesses an endoplasmic reticulum retention signal (HIEL) at its C-terminus.
Catalog #C3010-02C1
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 2ug/ml
Immunoprecipitation: 25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2B
Clone No11n45
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa19-563 from human CES-1 expressed in NS0 cells (P23141).
SpecificityRecognizes human CES-1. Species Crossreactivity: recombinant mouse CES-3. No cross-reactivity with rmCES-2, rmCES-5, or recombinant human CES-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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