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You are here:Home » Molecular Biology » MB-Serum Proteins » CETP, Control Peptide (Cholesteryl Ester Transfer Protein)

CETP, Control Peptide (Cholesteryl Ester Transfer Protein)

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Specifications

Synthetic Peptide C(131)DSGRVRTDAPD(142) (linear)
corresponding to the C-terminal amino acid residues 131-142 of human CETP protein.
Catalog #C3050-01A
Immunizing peptide corresponds to the C-terminal amino acid residues 131-142 of human CETP protein, C(131)DSGRVRTDAPD(142). Corresponds to anti-CETP C3050-01 which detects cholesteryl ester transfer protein (CETP) from human and rabbit tissues.
It has been proposed that high density lipoproteins (HDLs) function jointly with lecithincholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels.
CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to specifically accelerate the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. In general, elevated levels of CETP have been associated with increased risk of coronary heart disease.
ApplicationsSuitable for use in ELISA, Western Blotting neutralization and control experiments. Other applications not tested.
Recommended DilutionUsing a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
PurityPurified
Concentration~1mg/ml
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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