Chartreusin CAS 6377-18-0

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C3800 Chartreusin (Lambdamycin, NSC 5159, Antibiotic 747, Antibiotic 1293, Antibiotic X465A, Antibiotic G 261A) CAS: 6377-18-0

Specifications

References

CAS Number

6377-18-0

Grade

Highly Purified

Molecular Formula

C32H32O14

Molecular Weight

640.59600000000000364

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

4°C/-20°C

Lambdamycin, NSC 5159, Antibiotic 747, Antibiotic 1293, Antibiotic X465A, Antibiotic G 261A

Chartreusin is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. It inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals. Chartreusin is also potent inhibitor of topoisomerase II.

DMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water

Source

Streptomyces sp.

Purity

>99%

Form

Yellow solid

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Chartreusin, a new antibiotic produced by Streptomyces chartreusis, a new species. Leach, B.E. et al., J.Am.Chem.Soc. 1953, 75, 4011. 2. Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of topoisomerase II. Lorico A. and Long B.H. Eur. J. Cancer 1993, 14, 1985. 3. Chartreusin, elsamicin A and related anti-cancer antibiotics. Portugal J. Curr. Med. Chem. Anticancer Agents. 2003, 3, 411.