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You are here:Home » Antibodies » Abs to Binding Proteins » Anti -CHD1 (CHD1, CHD-1, Chromodomain helicase DNA binding protein 1)

Anti -CHD1 (CHD1, CHD-1, Chromodomain helicase DNA binding protein 1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IC
CHD1 (Chromohelicase/ATPase DNA-binding protein 1) is a 200-205kD member of the SNF2/RAD54 helicase family of proteins. It is an ATP-dependent chromatin remodeling factor that helps maintain chromatin in a transcriptionally active state. In embryonic stem cells, CHD1 associates with the promoters of active genes, a condition that is associated with open chromatin and pluripotency. Human CHD1 is 1710aa in length. It contains two Ser-rich regions (aa1-70 and 117-137), two Chromo (chromatin-organizer-modifer) domains (aa272-364 and 389-452), a SNF2 family N-terminal domain (aa484-763) and a C-terminal helicase domain (aa792-943). There are at least 30 Ser/Thr phosphorylation sites. Over aa1531-1710, human CHD1 shares 92aa identity with mouse CHD1.
Catalog #C3875-10E1
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml
Immunocytochemistry: 8-25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11n46
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa1531-1710 from human CHD1 expressed in E. coli (O14646).
SpecificityRecognizes human CHD1. No cross-reactivity with recombinant human CHD1L, 5, or 7.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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