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Anti -CHD1 (CHD1, CHD-1, Chromodomain helicase DNA binding protein 1)
Anti -CHD1 (CHD1, CHD-1, Chromodomain helicase DNA binding protein 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IC |
|
| CHD1 (Chromohelicase/ATPase DNA-binding protein 1) is a 200-205kD member of the SNF2/RAD54 helicase family of proteins. It is an ATP-dependent chromatin remodeling factor that helps maintain chromatin in a transcriptionally active state. In embryonic stem cells, CHD1 associates with the promoters of active genes, a condition that is associated with open chromatin and pluripotency. Human CHD1 is 1710aa in length. It contains two Ser-rich regions (aa1-70 and 117-137), two Chromo (chromatin-organizer-modifer) domains (aa272-364 and 389-452), a SNF2 family N-terminal domain (aa484-763) and a C-terminal helicase domain (aa792-943). There are at least 30 Ser/Thr phosphorylation sites. Over aa1531-1710, human CHD1 shares 92aa identity with mouse CHD1. | | | Catalog # | C3875-10E1 | | Applications | Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5ug/ml | | Immunocytochemistry: 8-25ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11n46 | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml. | | Purity | Purified by Protein A/G affinity chromatography. | | Immunogen | Recombinant corresponding to aa1531-1710 from human CHD1 expressed in E. coli (O14646). | | Specificity | Recognizes human CHD1. No cross-reactivity with recombinant human CHD1L, 5, or 7. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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