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You are here:Home » Antibodies » Abs to Binding Proteins » Anti -CHD3 (CHD-3, Chromodomain helicase DNA binding protein 3, Mi-2 alpha, Mi-2 autoantigen 240kD protein, ZFH, zinc-finger helicase (Snf2-like))

Anti -CHD3 (CHD-3, Chromodomain helicase DNA binding protein 3, Mi-2 alpha, Mi-2
autoantigen 240kD protein, ZFH, zinc-finger helicase (Snf2-like))

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
Catalog #C3875-50A
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.2mg/ml
FormTris-buffered Saline, 0.1% BSA
PurityPurified by immunoaffinity chromatography.
ImmunogenThe epitope recognized by this antibody maps to a region between residue 1575 and 1625 of human chromodomain helicase DNA binding protein 3 using the numbering given in entry NP_001005273.1 (GeneID 1107).
SpecificitySpecies Crossreactivity: Human. Other species not yet tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCHD3, CHD-3, Chromodomain helicase DNA binding protein 3, Mi-2 alpha, Mi-2 autoantigen 240kD protein, ZFH, zinc-finger helicase (Snf2-like)


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