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You are here:Home » Antibodies » Abs to Binding Proteins » Anti -CHD4 (CHD-4, Chromodomain Helicase DNA Binding Protein 4, Mi-2b, MI2-beta, Mi2 Autoantigen 218kD Protein)

Anti -CHD4 (CHD-4, Chromodomain Helicase DNA Binding Protein 4, Mi-2b, MI2-beta, Mi2
Autoantigen 218kD Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
CHD4/Mi2beta is a helicase component of the nucleosome remodeling and deacetylase (NuRD) complex that functions to remodel chromatin and repress transcription. Outside of the NuRD complex, CHD4/Mi2beta can function as an activator of transcription in association with p300 histone acetyltransferase. Alternate names for CHD4/Mi2beta include chromodomain-helicase-DNA-binding protein 4, CHD-4, ATP-dependent helicase CHD4, Mi-2 autoantigen 218kD protein, Mi2-beta, Mi-2b and DKFZp686E06161.
Catalog #C3880-25C
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionsWestern Blot: 1:2000-1:10,000
Immunoprecipitation: 2-5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in TBS, pH 7.2, 0.1% BSA, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenThe epitope recognized by this antibody maps to a region between residue 1625 and 1675 of human chromodomain helicase DNA binding protein 4 (Mi2 autoantigen 218kD protien).
SpecificityRecognizes human CHD4/Mi2 beta. Species Crossreactivity: Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCHD-4, Chromodomain helicase DNA binding protein 4, Mi-2b, MI2-beta, Mi2 autoantigen 218kD protein


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