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You are here:Home » Antibodies » Abs to Ubiquitin Ligases » Anti -CHIP (Carboxy Terminus of Hsp70-interacting Protein, Antigen NY-CO-7, CLL-associated Antigen KW-8, E3 Ubiquitin-protein Ligase CHIP, HSPABP2, NY-CO-7, PP1131, SDCCAG7, STIP1 Homology and U Box-containing Protein 1, STUB1, UBOX1)

Anti -CHIP (Carboxy Terminus of Hsp70-interacting Protein, Antigen NY-CO-7, CLL-associated
Antigen KW-8, E3 Ubiquitin-protein Ligase CHIP, HSPABP2, NY-CO-7, PP1131, SDCCAG7, STIP1
Homology and U Box-containing Protein 1, STUB1, UBOX1)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase(s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease.
Catalog #C4125-03H
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 0.3-1ug/ml, observed in human brain and skeletal muscle lysates on ~35kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-DAFISENGWVEDY, from human STUB1, at C-terminal (NP_005852.2).
SpecificityRecognizes human STUB1. Species sequence homology: Bovine, canine, mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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