Anti -CHIP (Carboxy Terminus of Hsp70-interacting Protein, Antigen NY-CO-7, CLL-associated
Antigen KW-8, E3 Ubiquitin-protein Ligase CHIP, HSPABP2, NY-CO-7, PP1131, SDCCAG7, STIP1
Homology and U Box-containing Protein 1, STUB1, UBOX1)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
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| CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase(s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease. | | | Catalog # | C4125-03H | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:32,000 | | Western Blot: 0.3-1ug/ml, observed in human brain and skeletal muscle lysates on ~35kD bands | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-DAFISENGWVEDY, from human STUB1, at C-terminal (NP_005852.2). | | Specificity | Recognizes human STUB1. Species sequence homology: Bovine, canine, mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -CHIP (Carboxy Terminus of Hsp70-interacting Protein, Antigen NY-CO-7, CLL-associated Antigen KW-8, E3 Ubiquitin-protein Ligase CHIP, HSPABP2, NY-CO-7, PP1131, SDCCAG7, STIP1 Homology and U Box-containing Protein 1, STUB1, UBOX1) |
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