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You are here:Home » Biochemicals » Biochem-Inhibitors » CHIR99021 (6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile, CT99021)

CHIR99021
(6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)am
ino)nicotinonitrile, CT99021)

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Specifications

A potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3b) (IC50 = 6.7nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402.
Catalog #C4137
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Protect from air. Light sensitive.
CAS Number252917-06-9
Molecular FormulaC22H18Cl2N8
Molecular Weight465.34
Purity~90% (HPLC).
FormSupplied as an off-white solid. Reconstitute with DMSO.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2- yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile, CT99021


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