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You are here:Home » Antibodies » Antibodies-Cancer Markers » Anti -Chk 1 (Ser280) (Checkpoint Kinase 1, CHEK1, CHK1, Serine/threonine-protein Kinase Chk1)

Anti -Chk 1 (Ser280) (Checkpoint Kinase 1, CHEK1, CHK1, Serine/threonine-protein Kinase


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
CHK1 prevents entry into mitosis when damaged or unligated DNA is detected by phosphorylating cdc25a, cdc25b, and cdc25c. Phosphorylation of cdc25c creates a binding site for protein 14-3-3, which inhibits cdc25c and prevents activation of the cdc2-cyclin b complex.
Catalog #C4200-10G
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to aa surrounding Ser 280 of human CHK1 (KLH).
SpecificityRecognizes human CHK1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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