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Anti -Chk 1 (Ser280) (Checkpoint Kinase 1, CHEK1, CHK1, Serine/threonine-protein Kinase Chk1)
Anti -Chk 1 (Ser280) (Checkpoint Kinase 1, CHEK1, CHK1, Serine/threonine-protein Kinase
Chk1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| CHK1 prevents entry into mitosis when damaged or unligated DNA is detected by phosphorylating cdc25a, cdc25b, and cdc25c. Phosphorylation of cdc25c creates a binding site for protein 14-3-3, which inhibits cdc25c and prevents activation of the cdc2-cyclin b complex. | | | Catalog # | C4200-10G | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.02% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic non-phosphopeptide corresponding to aa surrounding Ser 280 of human CHK1 (KLH). | | Specificity | Recognizes human CHK1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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