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You are here:Home » Biochemicals » Biochem-Antibiotics » Chloramphenicol



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Chloramphenicol is a chlorine-containing antibiotic produced by Streptomyces venezuelae. It has a wide spectrum of activity against gram-positive and gram-negative cocci and bacilli (including anaerobes), Rickettsia, Mycoplasma, and Chlamydia. It inhibits prokaryotic protein synthesis by attaching to the 50S ribosomal subunit. This inhibits peptidyltransferase, thereby preventing the formation of peptide bonds. It also inhibits protein synthesis in mitochondria which accounts for its toxic effects that cause aplastic anemia. Chloramphenicol has other adverse effects such as bone marrow depression, and gray baby syndrome. Itís use is limited to serious infections such as those where resistance to other antibiotics occurs. It is still widely used in the treatment of typhoid fever, meningitis and eye infections.
Catalog #C4350
Appearance White to off-white crystalline powder
SolubilityClear, colorless, complete
Chloramphenicol is slightly soluble in water. It is readily soluble in in alcohol, acetone, two monophosphate disodiumester
pH (2.5%)5.0-7.5
Specific Rotation +18.5°+20.0°
Melting Point 149-153°C
Loss on Drying 0.5%
Chlorides 0.5%
Suphated Ash 0.1%
Stock Concentration 10mg/ml
Working Concentration 20ug/ml
Meets or exceeds USP Specifications
CAS Number56-75-7
Molecular FormulaC11H12Cl2N2O5
Molecular Weight323.13
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesChloromycetin

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