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Specifications

Chloramphenicol is a chlorine-containing antibiotic produced by Streptomyces venezuelae. It has a wide spectrum of activity against gram-positive and gram-negative cocci and bacilli (including anaerobes), Rickettsia, Mycoplasma, and Chlamydia. It inhibits prokaryotic protein synthesis by attaching to the 50S ribosomal subunit. This inhibits peptidyltransferase, thereby preventing the formation of peptide bonds. It also inhibits protein synthesis in mitochondria which accounts for its toxic effects that cause aplastic anemia. Chloramphenicol has other adverse effects such as bone marrow depression, and gray baby syndrome. It’s use is limited to serious infections such as those where resistance to other antibiotics occurs. It is still widely used in the treatment of typhoid fever, meningitis and eye infections.
Catalog #	C4350
Appearance	White to off-white crystalline powder
Solubility (MeOH)	Colorless, clear, complete.
	Chloramphenicol is slightly soluble in water. It is readily soluble in in alcohol, propylene glycol, acetone, ethyl acetate.
Purity	98.5-102%
pH (2.5%)	5.0-7.5
Specific Rotation	+18.5°+20.0°
Melting Point	149-153°C
Stock Concentration	10mg/ml
Working Concentration	20ug/ml
	Meets or exceeds USP Specifications
CAS Number	56-75-7
Molecular Formula	C11H12Cl2N2O5
Molecular Weight	323.13
Purity	98.5-102%
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	Chloromycetin