chloride intracellular channel , Chloride channel ABP,|RNCC protein, Nuclear chloride ion channel 27, nuclear chloride ion channel protein, Regulatory nuclear chloride ion channel protein, chloride intracellular channel protein 1
Chloride intracellular channel protein 1 (CLIC1) is a part of the CLIC family of proteins. This family of proteins reconstitute in phospholipid vesicles and have been shown to have chloride channel action. CLIC1 may rotate between membrane-bound and soluble forms since it has been seen as a membrane protein and in the cytoplasm. When there is a lack of detergent, CLIC1 becomes membrane-bound and can act as an anion-selective channel. Recently, it has been shown that CLIC1 is required in angiogenesis and has a part in controlling integrin cell surface expression.
Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Western Blot: 0.25ug/ml detects CLIC1 on 10ug of human liver tissue lysate. Optimal dilutions to be determined by the researcher.
Positive Control
Human liver tissue lysate
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Full length recombinant protein corresponding to human CLIC1.|Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program.
Form
Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human CLIC1.
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